Nearby low-metallicity galaxies provide a crucial laboratory for understanding the interstellar medium, star formation, and feedback under conditions approaching those of the early Universe. Nowadays, modern facilities, such as the JWST, are also shinning a new light onto distant low-metallicity systems. This conference will bring together theorists and observers to discuss the following outstanding questions.

• How do ISM structure, phase balance, cooling, and dust properties evolve with metallicity, and how do these properties regulate star formation, including the roles of molecular hydrogen, CO-dark gas, and low-metallicity photodissociation regions?
• What is the impact of feedback from supernovae, stellar winds, to more extreme sources such as Population III stars, X-ray binaries, and intermediate-mass black holes?
• How can nearby dwarf galaxies inform high-redshift diagnostics and outline strategies for future facilities to detect and characterise faint, metal-poor galaxies and their circumgalactic environments?

 The event will welcome approximately 80 participants.

• Angela ADAMO (Stockholm University, Sweden)
• Guido DE MARCHI (ESA, Noordwijk, Netherlands)
• Frédéric GALLIANO (CEA Paris-Saclay, France; chair)
• Deidre HUNTER (Lowell Observatory, USA)
• Rémy INDEBETOUW (University of Virginia, Charlottesville, USA)
• Suzanne MADDEN (CEA Paris-Saclay, France; chair)
• Daniel SCHAERER (Université de Genève, Switzerland)
• Elizabeth TARANTINO (STScI, Baltimore, USA)